Oral and oropharyngeal malignancy: A clinicopathological study

Shubha P Bhat, Vadisha Srinivas Bhat, Harish Permi, Jayaprakash K Shetty, Rajeshwary Aroor, Satheesh Kumar Bhandary B

Abstract

Oral and oropharyngeal cancers are the commonest of head and neck malignancies. They share common etiological factors, which are often the personal habits of the patients. Human papillomavirus is increasingly being reported in patients with oral and oropharyngeal malignancies, especially in Western population. However in India, smoking, alcohol consumption and tobacco chewing are the common etiological factors. We conducted a retrospective study of 202 histopathologically confirmed cases of oral and oropharyngeal malignancies in Justice K.S. Hegde Charitable Hospital, Mangalore, during the three years period between January 2011 and December 2013. Majority of the patients were males. Buccal mucosa was the commonest site of lesions. Half of them had history of smoking, whereas the remaining had history of smokeless tobacco consumption. One-third of the patients had history of alcohol consumption. However, 10.8% of the patients had no addictions and this group was dominated by females.


Citation

Bhat SP, Bhat V, Permi H, Shetty K J, Aroor R, Bhandary BSK. IJPLM. 2016;2(1):OA3 (Republished: 22 December 2016)

Keywords

Oral cavity; Oropharynx; Malignancy; Habits

References

1. Warnakulasuriya S. Global epidemiology of oral and oropharyngeal cancer. Oral oncology. 2009;45:309-316.

2. Sankaranarayanan R, Ramadas K, Thomas G, Muwong R, Thara S, Mathew B,et al. Effect of screening on oral cancer mortality in Kerala, India: a cluster-randomised controlled trialLancet 2005; 365: 1927–33

3. Gillison ML. Current topics in the epidemiology of oral cavity and oropharyngeal cancers. Wiley interscience, head and neck. 2007:779-788.

4. Patel MM, Pandya AN. Relationship of oral cancer with age, sex, site distribution and habits. Indian J Pathol Microbiol 2004;47(2):195-197

5. Durazzo MD, Araujo CEN, Neto JSB, Potenza AS, Costa Pedro, Takeda F et al. clinical and epidemiological features of oral cancer ina medical school teaching hospital from 1994 to 2002: increasing incidence in women, predominance of advanced local disease, and low incidence of neck metastases.CLINICS 2005;60(4)293-298.

6. Balaram P, Sridhar H, Rajkumar T, Vaccarella S, Herrero R, Nandakumar A, et al. Oral cancer in Southern India: The influence of smoking, drinking, paan-chewing and oral hygiene. Int J Cancer 2002;98:440-445

7. Muwonge R, Ramadas K, Sankila R, Thara S, Thomas G, Vinoda J, et al. Role of tobacco smoking, chewing and alcohol drinking in the risk of oral cancer in Trivandrum, india: A nested case-control design using incident cancer cases. Oral oncol 2008;44: 446-454.

8. Bhat SP, Ramesh NCN, Swetadri GK, D’souza H, Jayaprakash CS, Bhat V. Clinicopathological spectrum of malignancies of oral cavity and oropharynx – our experience in a referral hospital. World articles in Ear, Nose and Throat. 2010;3(2).

9. Brandizzi D, Gandolfo M, Velazco ML, Cabrini RL, Lanfranchi HE. Clinical features and evolution of oral cancer: A study of 274 cases in Buenos Aires, Argentina. Med Oral Patol Oral Cir Bucal.2008;13(9):544-548.

10. Abhinandan B, Chakraborty A, Purkaystha P. Prevalence of head and neck cancers in the North East-An institutional study. Indian J Otolaryngol Head Neck Surg 2006;58:15-19

11. Ahluwalia H, Gupta SC, Singh M, Gupta SC, Mishra V, Singh PA, et al. Spectrum of Head -Neck cancers at Allahabad. Indian J Otolaryngol Head Neck Surg 2001;53(1):16-21

12. Dias GS, Almeida AP. A histological and clinical study on oral cancer:Descriptive analysis of 365 cases. Med Oral Patol Oral Cir Bucal.2007;12(7):474-478

13. Blot WJ, McLaughlin JK, Winn DM. Smoking and drinking in relation to oral and pharyngeal cancer. Cancer Res 1988;48:3282-3287.

14. Brooks PJ, Theruvathu JA. DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis. Alcohol 2005;35:187–193

15. Rodu B, Jansson C. Smokeless tobacco and oral cancer: a review of the risks and determinants. Crit Rev Oral Biol Med 2004;15:252–263.

16. Znaor A, Brennan P, Gajalakshmi V, et al. Independent and combined effects of tobacco smoking, chewing and alcohol drinking on the risk of oral, pharyngeal and esophageal cancers in Indian men. Int J Cancer 2003;105:681–686.

17. Yarbrough WG, Aprelikova O, Pei H, Olshan AF, Liu ET. Familial tumor syndrome associated with a germline nonfunctional p16INK4a allele. J Natl Cancer Inst 1996; 88:1489–1491.

18. Wahid A, Ahmad S, Sajjad M. Pattern of carcinoma of oral cavity reporting at dental department of ayub medical college.2009

19. Ahmed F, Islam KM. Site predilection of oral cancer and its correlation with chewing and smoking habit-a study of 103 cases.Bangladesh Med Res Counc Bull.1990;16(1): 17-25.

20. Moore SR, Johnson NW, Pierce AM, Wilson DF. The epidemiology of tongue cancer: a review of global incidence. Oral Dis 2000;6:75–84.

21. More Y, D’cruz A. Oral cancer: Review of current management strategies. Natl Med J India. 2013;26(3):152-8.

22. Iype EM, Pandey M, Mathew A, Thomas G, Sebastian P, Nair MK. Oral cancer among patients under the age of 35 years. J Postgrad Med 2001;47(3):171-176.

23. Mehrotra R, Mamata S, Kishore GR, Manish S, Kapoor AK. Trends of prevalence and pathological spectrum of head and neck cancers in North India. Indian J Cancer 2005;42(2):89-93.