An unusual presentation of adenosquamous carcinoma of gallbladder

Shariff MH, Shubha P Bhat, Kishan Prasad H L

Abstract

Carcinoma of the gallbladder is the most common malignancy of the biliary tract. Although adenocarcinomas account for more than 90% of gallbladder cancers, the incidence of adenosquamous carcinomas (ASCs) is only approximately 5%. ASCs have aggressive biological behavior due to their potential for direct extension into the liver and neighboring structures like stomach, duodenum, and transverse colon. In most cases, the disease would have advanced at the time of diagnosis and the prognosis might be dismal when compared to ordinary adenocarcinoma of the gallbladder. We present here a rare case of ASC of gallbladder in a 59-yr-old female who presented with right upper abdominal pain.


Citation

Shariff MH, Bhat SP, Prasad HLK. IJPLM. 2016;2(1):CS2 (Republished: 22 December 2016)

Keywords

adenosquamous; gallbladder; carcinoma; wedge resection

References

1. Mingoli A, Brachini G, Petroni R, Antoniozzi A, Cavaliere F, Simonelli L et al. Sqaumous and adenosquamous cell carcinomas of the gallbladder. J Exp Clin Cancer Res. 2005 Mar;24(1):143-50.

2. Bagdasaryan R, Miroshnichenko H. Adenosquamous cell carcinoma of the gallbladder. Images in medicine 2011;94(1):19.

3. Rustagi T, Rai M, Menon M. Ruptured adenosquamous cell carcinoma of the gallbladder: Case report and review of literature. Case reports in GI oncology 2011;4(1):29-32.

4. Levy AD, Murakata LA, Rohrmann CA. Gallbladder carcinoma: radiologic pathologic correlation. AFIP Archives 2001;2(2):295-314.

5. Miao X, Yang ZL, Xiong L, Zou Q, Yuan Y, Li J, et al. Nectin-2 and DDX3 are biomarker for metastasis and poor prognosis of squamous cell/adenosquamous carcinomas and adenocarcinoma of gallbladder. Int J ClinExpPathol 2013;6(2):179-90.

6. Roa JC, Tapia O, Cakir A, Basturk O, Dursun N, Akdemir D et al. Squamous cell and adenosquamous carcinomas of the gallbladder: clinicopathological analysis of 34 cases identified in 606 carcinomas. Modern Pathology 2011;24(8):1069-78.

7. Singh S, Ansari MA, Narayan G. Pathobiology of gall bladder cancer. J Scientific Research 2012;56:35-45.