Correlation of Lauren’s histological type and expression of E-cadherin and HER-2/neu in gastric adenocarcinoma

Khushboo Dewan, Renu Madan, Prasanta Sengupta

Abstract

Background: To evaluate whether a proven association between clinicopathological features and expression of molecular markers could provide a clue towards the relevance of these markers in gastric adenocarcinoma (GAC).

Aims: The present study aimed to find any relation between immunohistochemical expression of E-cadherin and HER-2/neu proteins, and Lauren’s histological type and stages of GAC.

Materials and Methods: 100 cases of primary GAC diagnosed on biopsy or gastrectomy were included in the study. Immunohistochemical expression of E-cadherin and HER-2/neu was studied with respect to site, Lauren’s histological type, and stages of GAC.

Results: A total of 11 cases showed a loss of E-cadherin expression and 17 cases overexpressed HER-2/neu. Loss of E-cadherin was seen in 26% of Lauren’s diffuse type, but only in 5.7% of intestinal GAC (P=0.014). While 35% of the GAC present at greater curvature showed HER-2/neu overexpression, whereas 16% at antro-pyloric region and none at lesser curvature showed HER-2/neu overexpression (P=0.04). All of the 17 HER-2/neu overexpressing GAC were Lauren’s intestinal type (P=0.012).

Conclusion: Loss of E-cadherin and HER-2/neu overexpression are associated with Lauren’s diffuse and intestinal type respectively. Anti-HER-2/neu monoclonal antibody therapy would be helpful in approximately one-fifth of gastric adenocarcinoma patients.


Citation

Dewan K, Madan R, Sengupta P. IJPLM 2016;2(1):OA2. (Republished: 21 December 2016)

Keywords

E-cadherin, Gastric adenocarcinoma, HER-2/neu, Lauren’s classification

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