Mycobacterium theory regarding pathogenesis of Takayasu’s arteritis: Numerous unsolved dilemmas

Arun R Chogle, Sachin Jain, Harshul Kushwaha
DOI: 10.15305/ijrci/v3i1/134

Abstract

Mycobacterium tuberculosis (Mtb) has been implicated in the pathogenesis of Takayasu’s arteritis (TA), but there is no direct evidence substantiating the association. Several cases series and laboratory studies provide indirect evidence on the role of Mtb and other related species in the immunopathogenesis of TA. This association could be explained by the molecular mimicry between mycobacterium heat shock protein (mHSP 65) and the human homologue (hHSP60) driving immune response in TA. Two different histopathological studies that have evaluated the presence of mycobacteria in aortic tissue have reported contradictory results. This may be due to regional differences in the prevalence of Mtb, ethnicity, and study methodology. Recent progress in identifying susceptibility genes and study of TNFα-308 gene polymorphism has opened up new avenues for research on mycobacterium theory. Based on the currently available data, three different models have been proposed. Among these, two models favor the mycobacterium theory, while one does not. Transcriptomic and proteomic studies of mycobacteria could help in identifying specific or common traits of mycobacteria that are relevant to the development and reactivation of TA.




Citation

Chogle AR, Jain S, Kushwaha H. IJRCI. 2015;3(1):R2 (14 July 2015) DOI: 10.15305/ijrci/v3i1/134

Keywords

Key words:- Takayasu's arteritis Tuberculosis Tuberculosis Histology Molecular mimicry

References

1. Shimizu K, Sano K. Pulseless disease. Clin. Surg. (Tokyo). 1948;3:377.

2. Long R, Guzman R, Greenberg H, Safneck J, Hershfield E. Tuberculous mycotic aneurysm of the aorta: review of published medical and surgical experience. Chest. 1999 Feb;115(2):522–31.

3. Picard C, Parrot A, Boussaud V, Lavolé A, Saidi F, Mayaud C, et al. Massive hemoptysis due to Rasmussen aneurysm: detection with helicoidal CT angiography and successful steel coil embolization. Intensive Care Med. 2003 Oct;29(10):1837–9.

4. Pantell RH, Goodman BW. Takayasu’s arteritis: the relationship with tuberculosis. Pediatrics. 1981 Jan;67(1):84–8.

5. Kinare SG. Aortitis in early life in India and its association with tuberculosis. J Pathol. 1970 Jan 1;100(1):69–76.

6. Chogle AR, Shah DA, Cerejo C. Analysis of evidence to determine the link between Takayasu’s arteritis and Tuberculosis. Indian Journal of Rheumatology. 2015 Mar;10(1):2–9.

7. Duzova A, Türkmen O, Cinar A, Cekirge S, Saatci U, Ozen S. Takayasu’s arteritis and tuberculosis: a case report. Clin Rheumatol. 2000;19(6):486–9.

8. Kontogiannis V, Dalziel KL, Powell RJ. Papulonecrotic tuberculide and stenosis of the abdominal aorta. Rheumatology (Oxford). 2000 Feb;39(2):205–8.

9. Modi G, Modi M. Cold agglutinins and cryoglobulins in a patient with acute aortoarteritis (Takayasu’s disease) and tuberculous lymphadenitis. Rheumatology (Oxford). 2000 Mar;39(3):337–8.

10. Baijal R, Chogle AR, Kumar P, Shah N, Kulkarni S, Doshi S, et al. A case of tuberculous colitis with associated Takayasu’s arteritis. J Assoc Phys India 2015; 63:62-65.

11. Subramanyan R, Joy J, Balakrishnan KG. Natural history of aortoarteritis (Takayasu’s disease). Circulation. 1989 Sep;80(3):429–37.

12. Karadag O, Aksu K, Sahin A, Zihni FY, Sener B, Inanc N, et al. Assessment of latent tuber-culosis infection in Takayasu arteritis with tuberculin skin test and Quantiferon-TB Gold test. Rheumatol Int. 2010 Sep;30(11):1483–7.

13. Kumar Chauhan S, Kumar Tripathy N, Sinha N, Singh M, Nityanand S. Cellular and hu-moral immune responses to mycobacterial heat shock protein-65 and its human homologue in Takayasu’s arteritis. Clin Exp Immunol. 2004 Dec;138(3):547–53.

14. Seko Y, Minota S, Kawasaki A, Shinkai Y, Maeda K, Yagita H, et al. Perforin-secreting killer cell infiltration and expression of a 65-kD heat-shock protein in aortic tissue of patients with Takayasu’s arteritis. J Clin Invest. 1994 Feb;93(2):750–8.

15. Arnaud L, Haroche J, Mathian A, Gorochov G, Amoura Z. Pathogenesis of Takayasu’s arte-ritis: a 2011 update. Autoimmun Rev. 2011 Nov;11(1):61–7.

16. Park MC, Lee SW, Park YB, Lee SK. Serum cytokine profiles and their correlations with disease activity in Takayasu’s arteritis. Rheumatology (Oxford). 2006 May;45(5):545–8.

17. Tripathy NK, Chauhan SK, Nityanand S. Cytokine mRNA repertoire of peripheral blood mononuclear cells in Takayasu’s arteritis. Clin Exp Immunol. 2004 Nov;138(2):369–74.

18. Sandhya P, Danda S, Danda D, Lonarkar S, Luke SS, Sinha S, et al. Tumour necrosis factor (TNF)-α-308 gene polymorphism in Indian patients with Takayasu’s arteritis - A pilot study. Indian J Med Res. 2013 Apr;137(4):749–52.

19. Chen R, Fang M, Cai Q, Duan S, Lv K, Cheng N, et al. Tumor necrosis factor alpha -308 polymorphism is associated with rheumatoid arthritis in Han population of Eastern China. Rheumatol Int. 2007 Dec;28(2):121–6.

20. Lv N, Dang A, Zhu X, Liu Y, Liu Y, Zheng D, et al. The role of tumor necrosis factor-α promoter genetic variation in Takayasu arteritis susceptibility and medical treatment. J Rheumatol. 2011 Dec;38(12):2602–7.

21. Soto ME, Ávila-Casado MDC, Huesca-Gómez C, Alarcon GV, Castrejon V, Soto V, et al. Detection of IS6110 and HupB gene sequences of Mycobacterium tuberculosis and bovis in the aortic tissue of patients with Takayasu’s arteritis. BMC Infectious Diseases. 2012 Aug 20;12(1):194.

22. Arnaud L, Cambau E, Brocheriou I, Koskas F, Kieffer E, Piette J-C, et al. Absence of My-cobacterium tuberculosis in Arterial Lesions from Patients with Takayasu’s Arteritis. J Rheumatol. 2009 Aug 1;36(8):1682–5.

23. Lee HS, Park KU, Park JO, Chang HE, Song J, Choe G. Rapid, sensitive, and specific detection of Mycobacterium tuberculosis complex by real-time PCR on paraffin-embedded human tissues. J Mol Diagn. 2011 Jul;13(4):390–4.

24. Role of real-time PCR (RT-PCR) in rapid diagnosis of tuberculous mycobacteria in different clinical samples. J Indian Med Assoc. 2014 Feb;112(2):81–4.

25. Prabhakar S, Mishra A, Singhal A, Katoch VM, Thakral SS, Tyagi JS, et al. Use of the hupB gene encoding a histone-like protein of Mycobacterium tuberculosis as a target for detec-tion and differentiation of M. tuberculosis and M. bovis. J Clin Microbiol. 2004 Jun;42(6):2724–32.

26. Castillo-Martínez D, Amezcua-Guerra LM. Self-reactivity against stress-induced cell mole-cules: the missing link between Takayasu’s arteritis and tuberculosis? Med Hypotheses. 2012 Apr;78(4):485–8.

27. Hoffman GS. Large-vessel vasculitis: unresolved issues. Arthritis Rheum. 2003 Sep;48(9):2406–14.

28. Panda A, Kurapati S, Samantaray JC, Myneedu VP, Verma A, Srinivasan A, et al. Rapid identification of clinical mycobacterial isolates by protein profiling using matrix assisted laser desorption ionization-time of flight mass spectrometry. Indian J Med Microbiol. 2013 Jun;31(2):117–22.

29. Bonde BK, Beste DJV, Laing E, Kierzek AM, McFadden J. Differential producibility analy-sis (DPA) of transcriptomic data with metabolic networks: deconstructing the metabolic response of M. tuberculosis. PLoS Comput Biol. 2011 Jun;7(6):e1002060.