Anti-SRP antibody related inflammatory myositis: A heterogeneous group of necrotizing myositis

Jeet Hemantkumar Patel, Lalit Duggal, Neeraj Jain, Gurbir Bhandari
DOI: 10.15305/ijrci/v6i1/261


Anti-SRP antibody related necrotizing myositis is a rapidly progressive, severe, proximal muscle weakness with atrophy. The present study deals with two cases with poor prognostic course, concluding anti-SRP antibody related myositis as a heterogeneous group of inflammatory myositis. One patient had subacute onset proximal muscle weakness of both lower limbs, raised CPK, and biopsy showing typical changes of anti-SRP related necrotizing myositis. He responded well to steroids and methotrexate.  The other patient had 3 months history of subacute onset weakness of both lower limb and was admitted with quadriparesis, bulbar palsy, aspiration pneumonia and respiratory distress. Even after treatment with intravenous immunoglobulin, broad spectrum antibiotics, steroids, and ventilatory support, the patient succumbed to the illness


Patel JH, Duggal L, Jain N, Bhandari G. IJRCI. 2018;6(1):CS3 DOI: 10.15305/ijrci/v6i1/261


anti-SRP myositis, necrotising myositis, immunosuprresants, heterogeneous


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