Histopathology of lupus nephritis: A single-center, cross-sectional study from Karnataka, India

Vineeta Shobha, Ravi Prakash, Preetha Arvind, SD Tarey
DOI: 10.15305/ijrci/v2i1/80


A cross-sectional study of SLE patients over a period of two years is reported. Renal biopsy of 32 selected patients revealed histopathological abnormalities and deposits of immune complexes, and were classified according to the WHO classification of LN (lupus nephritis). The clinical and laboratory parameters assessed were also in line with this classification, indicating the adequacy of these parameters for routine follow-up, and the biopsy was reserved for advanced cases of LN.


Shobha V, Prakash R, Arvind P, Tarey SD. IJRCI. 2014;2(1):OA3 (23 July 2014) DOI: 10.15305/ijrci/v2i1/80


Systemic lupus erythematosus; Renal manifestations; Lupus nephritis; Activity index; chronicity index.


1. Manzi SM, Stark VE, Ramsey-Goldman R. Systemic lupus erythematosus: epidemiology and classification of systemic lupus erythematosus. In: Hochberg MC, Silman AJ, Smolen JS, et al. ed. Rheumatology,3rd ed. St. Louis: CV Mosby; 2003:1291-1296

2. Uramoto KM, Michet CJ Jr, Thumboo J, Sunku J, O’Fallon WM, Gabriel SE. Trends in the incidence and mortality of systemic lupus erythematosus, 1950-1992. Arthritis Rheum. 1999 Jan;42(1):46-50.

3. Kumar A, Malaviya AN, Singh RR, Singh YN, Adya CM, Kakkar R. Survival in patients with systemic lupus erythematosus in India. Rheumatol Int. 1992 Jul 1;12(3):107-109.

4. Gladman DD, Urowitz MB. Systemic lupus erythematosus: clinical features. In: Hochberg MC, Silman AJ, Smolen JS, et al. ed. Rheumatology. 3rd ed. St. Louis: CV Mosby; 2003:1359-1379.

5. Nossent HC, Henzen-Logmans SC, Vroom TM, Berden JH, Swaak TJ. Contribution of renal biopsy data in predicting outcome in lupus nephritis.Analysis of 116 patients. Arthritis Rheum. 1990 Jul;33(7):970-977.

6. Morris MC, Cameron JS, Chantler C, Turner DR. Systemic lupus erythematosus with nephritis. Arch Dis Child. 1981 Oct;56(10):779-783.

7. Esdaile JM, Levinton C, Federgreen W, Hayslett JP, Kashgarian M. The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: a study of 87 patients and review of the literature. Q J Med. 1989 Sep;72(269):779-833.

8. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271-1277.

9. Appel GB, Silva FG, Pirani CL, Meltzer JI, Estes D. Renal involvement in systemic lupud erythematosus (SLE): a study of 56 patients emphasizing histologic classification. Medicine (Baltimore). 1978 Sep;57(5):371-410.

10. Baldwin DS, Lowenstein J, Rothfield NF, Gallo G, McCluskey RT. The clinical course of the proliferative and membranous forms of lupus nephritis. Ann Intern Med. 1970 Dec;73(6):929-942.

11. Budman DR, Steinberg AD. Hematologic aspects of systemic lupus erythematosus. Current concepts. Ann Intern Med. 1977 Feb;86(2):220-229.

12. Fries JF, Powers R, Kempson RL. Late-stage lupus nephropathy. J Rheumatol. 1974 Jun;1(2):166-175.

13. Parichatikanond P, Francis ND, Malasit P, Laohapand T, Nimmannit S, Singchoovong L, et al. Lupus nephritis: clinicopathological study of 162 cases in Thailand. J ClinPathol. 1986 Feb;39(2):160-166.

14. Austin HA 3rd, Boumpas DT, Vaughan EM, Balow JE. Predicting renal outcomes in severe lupus nephritis: contributions of clinical and histologic data. Kidney Int. 1994 Feb;45(2):544-550.

15. Neumann K, Wallace DJ, Azen C, Nessim S, Fichman M, Metzger AL, et al.. Lupus in the 1980s: III. Influence of clinical variables, biopsy, and treatment on the outcome in 150 patients with lupus nephritis seen at a single center. Semin Arthritis Rheum. 1995 Aug;25(1):47-55.

16. Gladman DD, Urowitz MB, Cole E, Ritchie S, Chang CH, Churg J. Kidney biopsy in SLE. I. A clinical-morphologic evaluation. Q J Med. 1989 Dec;73(272):1125-1133.

17. Pollak VE, Pirani CL, Schwartz FD. The natural history of the renal manifestations of systemic lupus erythematosus. J Lab ClinMed. 1964 Apr;63:537-550.

18. Hans C. N, Sonja C et al. Contribution of renal biopsy data in predicting outcome in Lupus Nephritis. Arthritis Rheumat. 1990. 33(7): 970-977.

19. Rajaee A, Behzadi S, Bazmi S, Moayeri M. The clinical and pathologic findings among patients with lupus nephritis in Shiraz, South Iran. SMJ 2005;6:5-9.

20. Yoo CW, Kim MK, Lee HS. Predictors of renal outcome in diffuse proliferative lupus nephropathy: data from repeat renal biopsy. Nephrol Dial Transplant. 2000 Oct;15(10):1604-1608.

21. Budman DR, Steinberg AD. HYpertension and renal disease in systemic lupus erythematosus. Arch Intern Med. 1976 Sep 1;136(9):1003-1007.

22. Wallace DJ. The clinical presentation of SLE. In: Wallace DJ, Hahn BH, eds. Dubois’s systemic lupus erythematosus. 4th ed. Philadelphia: Lea & Febiger 1992;317­321.