Clinical and immunological profile of SLE patients: Experience from a Chennai-based tertiary care centre (revisited)
Keywords:
immunological profile, SLE patients, systemic lupus erythematosus, ACR, clinicoepidemiologicalAbstract
Aim: To study the clinical and immunological profile of patients with newly detected systemic lupus erythematosus (SLE) presented to a tertiary care centre.
Methods: The study involved patients with newly detected SLE (fulfilling the 1997 revised ACR criteria for SLE), admitted in Madras Medical College and Rajiv Gandhi Government General Hospital Chennai between January 2012 and December 2013.
Results: Hundred patients with SLE were assessed for a period of two years, among them, 59% of the subjects belonged to the 3rd decade of life; 86% of the subjects were females and the remaining were males (M:F ratio 6:1). Fever (81%) was the commonest initial manifestation reported, followed by arthritis (61%), cutaneous (58%), neuropsychiatric (45%), and renal (44%) manifestations. In patients with lupus nephritis, class IV (38.63%) was common, followed by class III (22.72%) and class V (15.9%). ANA was positive in all patients (100%), anti-Smith (Sm) was found in 49% of the subjects, followed by anti-Ro (47%), anti-ds DNA (45), anti U1 RNP (42%) and reduced complements in 72%.
References
Madhavan R. S LE – The Madras Experience. J Assoc Phys India 1988; 36:481-484.
Saigal R, Kansal A, Mittal M, Singh Y, Maharia HR, Juneja M. Clinical profile of systemic lupus erythematosus patients at a tertiary care centre in Western India. J Indian Acad Clin Med. 2011;13:27–32.
Paul BJ, Fassaludeen M, Nandakumar, Razia MV. Clinical profile of Systemic Lupus Erythematosus in Northern Kerala. JIndian Rheumatol Assoc 2003; 11: 94-7.
Malaviya AN, Singh RR, Kumar A, De A, Kumar A, Aradhye S. SLE in Northern India. A review of 329 cases. J Assoc Phys India 1988; 36: 476-80.
Vaidya S, Samant RS, Nadkar MY, Borges NE. SLE- review of two hundred and twenty patients. JIRA 1997; 5: 14-8.
