Understanding the role of scavenger receptor CD36 in modulation of dendritic cell responses
Keywords:
Dendritic cells, DCs, antigen-presenting cells, APCs, PAMPs, CD36, scavenger receptor, TLR2Abstract
Introduction: Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that play a central role in immunity. DCs, like other innate immune cells, usually rely on various germ-line encoded pattern recognition receptors (PRRs) to recognize some of the conserved patterns, called pathogen-associated molecular patterns (PAMPs), on microbes. Recent studies from various groups highlight the emergence of scavenger receptors (SRs) as non-classical PRRs.